Tuesday, June 08, 2004
Another Oddity of Medical Science
Now, we see an indication that surgical treatment of sleep apnea can result in measurable improvements in anxiety and depression -- and the degree of psychiatric improvement is not strongly associated with the changes in objective tests.
In this study, the objective tests included measurements of the frequency of apneas (periods of interrupted breathing), and measurement of blood oxygen saturation (how much oxygen is present in the arterial blood.) Overall sleepiness was assessed using the Epworth Sleepiness Scale. (See link in sidebar.)
Laryngoscope. 114(6):1098-1102, June 2004.
Li, Hsueh-Yu MD; Huang, Yu-Shu MD; Chen, Ning-Hung MD; Fang, Tung-Jen MD; Liu, Chia-Yih MD; Wang, Pa-Chun MD, MSc
Abstract:
Objective: Patients with obstructive sleep apnea (OSA) may experience
unfavorable psychologic symptoms such as depression and anxiety. The
aim of this study was to confirm this hypothesis and to investigate
whether the psychologic symptoms among OSA patients can be relieved by
surgical intervention.
Study Design: Prospective, longitudinal intervention study.
Methods:
The 5-Item Mental Health scale (MH-5) was used to evaluate the
postoperative changes of mood after extended uvulopalatal flap (EUPF)
surgery on 84 Taiwanese patients with OSA. The preoperative and
postoperative MH-5 data obtained from these patients were compared with
a Taiwanese population norm.
Results: Before surgery, the MH-5 scores of the OSA patients were significantly worse than the Taiwanese population norm of 72.8 (P < .0001). Postoperatively, mean MH-5 scores significantly increased from 61.8 +/- 16.0 to 70.0 +/- 15.8 (P = .0006). The effect size of this score change was 0.51, indicating a moderate degree of mood improvement. However, this score was still inferior to that of the population norm (P = .0045). The mood improvement was not significantly associated with the changes in either sleep apnea events or the level of sleepiness. Neither the changes in respiratory disturbance index (P = .4382), maximum arterial oxygen saturation (P = .4866), nor the change in Epworth Sleepiness Scale scores (P = .4951) were predictive of the MH-5 score improvement (R2 = 0.07).
Conclusions: This study demonstrated that patients with OSA had a higher level of anxiety, depression, and probable behavior or personality changes than the population norm. EUPF surgery could significantly improve the mood status among OSA patients; the effect of surgery was mild but clinically relevant. However, the extent of mood improvement experienced by OSA patients receiving operations may not simply be attributable to the changes in sleep apnea events or a reduced level of sleepiness.
(C)
The American Laryngological, Rhinological & Otological Society, Inc.
I am not familiar with the instrument they used to assess psychiatric symptoms: the MH-5. It is not widely used in psychiatry, so there is a chance that it is not really a valid measure of clinical syndromes. Taking it at face value, though, assuming the MH-5 actually means something, it would be of great interest to look at the individual patients, see which ones got the greatest mental health boost from the surgery, and try to figure out what is different about them, as compared to the patients who had the surgery but did not have improvements in mood and anxiety.
The reason this is important is that psychiatric disorders are defined by symptoms, not by underlying causes. This is a known problem in psychiatric research. Everyone in the field wants to come up with so way of subdividing the population of depressed patients into groups that would correlate with treatment responses. That way, we would not end up given treatments that are not likely to work, to patients who really need some other kind of treatment.
With the exception of atypical depression (which responds preferentially to MAOI's) and psychotic depression (which responds preferentially to a combination of an antidepressant and an antipsychotic), we have not had much success in subdividing the types of depression into clinically relevant groups. There is hope that functional neuroimaging -- fMRI and PET -- could be useful in this regard. So far, however, all we have is tantalizing clues; nothing really useful has come of it so far. If there is a relationship between sleep architecture and subtypes of depression, that would be good to know.
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Monday, June 07, 2004
More Facts About Antidepressants and Suicide
Now, however, the interest in the topic has waned; people just aren't talking about it so much any more. Despite the fickle nature of the sensational-news-consuming public, the scientific community has retained an interest in the topic.
Yes, there was an article in the NYT last week, regarding a study that showed a positive effect using fluoxetine to treat depressed adolescents. This article did not attract much attention, which, in fact, was appropriate. Few few individual studies deserve front-page coverage in a major newspaper. Although the results of the study were encouraging, any such study must be viewed in a wider context in order to be interpreted properly.
Because of the need for a wider context, it was with interest that I read the recent article in the Psychiatric Times. The article reviews the findings of five population-based studies of the association between antidepressant prescribing and suicide rates.
The entire report is fairly short, so it would be almost as easy to ask readers to just go read the entire thing, as opposed to providing excerpts here. However, the article is rather technical, enough so that I imagine it would take a sustained effort of will to plow through it.
This is one of those articles that starts out by reviewing studies that reported negative findings, then goes into the ones that show positive findings, then shows why we should believe the positive findings and not the negative ones. Therefore, persons who have already made up their minds should not bother reading it. If you have decided already what you believe, this article will not change your mind. If, on the other hand, you are willing to be open-minded about it, you may find it sways you one way or the other.
Is Antidepressant Prescribing Associated With Suicide Rates?
by Philip B. Mitchell, M.D., MB, FRCPsychPsychiatric Times May 2004 Vol. XXI Issue 6
First, the negative findings:Next, the limitations of the negative findings:
Next, the positive findings:
Next, the author's own findings, which, in their view, indicate that the positive findings are the ones we should pay attention to:
One of the complexities that faced us, however, was that the total suicide rate for Australian men and women did not change between 1991 and 2000, because marked decreases in suicide rates in older men and women were offset by increases in younger adults, especially young men. A similar phenomenon has been observed in the United Kingdom, where suicide rates doubled in males younger than 45 between 1950 and 1998, but rates declined in older males and females of all ages (Gunnell et al., 2003). Because of this phenomenon, we analyzed differences in suicide trends between men and women in different age groups to assess whether age and gender rates in suicide were related to differences between these groups in exposure to antidepressant medication (Hall et al., 2003).
Then, more supporting evidence:
The author is careful to point out that such corellations do not establish causation. They do, however, argue against the proposition that antidepressant medication is more likely to cause suicidal behavior than it is to prevent it.
Note that the studies cited by the author are studies of adult populations. The recent controversy had more to do with the risks of using antidepressant medication in children and adolescents. It looks as though we will have to wait for more definitive information on that issue.
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Sunday, June 06, 2004
The Passing of another American Icon
This got me to thinking: I feel bad that I missed the opportunity to commemorate the death of another great American Icon.
Back on April 22, 2004, it was the twentieth anniversary of the death of Ansel Easton Adams. (born 2-20-1902 in San Francisco, California
died 4-22-1984 in Monterey, California, at age 82)
In this post, I explain why Ansel Adams was an American icon, and why I still have some respect for Ronald Reagan.
From David Hume Kennedy's article:
[...] Ansel was a big bear of a man, hearty and good natured. But during the meeting with Ford, despite the bluntness of his words, he spoke in soft tones, and the president responded in kind, often leaning in to hear more clearly. I think that one of the things that attracted Ansel to the president was that, like himself, Ford was a very modest, self-effacing man.
As a result of the meeting, President Ford wrote to Ansel agreeing with him that the policies of the Park Service "needed a fresh look," and reported to him that he had commissioned a task force to redefine the priorities of the service. He also reiterated in the letter his commitment to the national park system, and among other things, supported Ansel's desire to preserve open space close to large urban centers, which would serve local recreation programs.
The 74-year-old photographer's letter and proposals struck a deep chord within the president. On Aug. 29, 1976, against the backdrop of Yellowstone National Park, Republican President Gerald R. Ford stunned the environmental world. He announced that he would be submitting to Congress the "Bicentennial Land Heritage Act," a 10-year, $1.5 billion commitment to double the present acreage for national parks, recreation areas and wildlife sanctuaries.
"Moon and
Half Dome" |
If you
are interested in Presidential history, I urge you to read
Kennedy's article about Ford and Adams. It is an interesting
study of personalities. As a clinical aside, both personalities
were psychologically healthy, although very different. Given the rapprochement between Adams and Ford, one would be tempted to assume that a subsequent meeting between Ansel Adams and Ronald Reagan would have a amicable and positive outcome. Not so. "This visage meek and humble, and hear this confidential plea voiced in reverent mumble: give me Shylock, give me Fagin but, oh God, spare me Ronald Reagan!" - Ansel Adams This quote appears on timmareca.com; I cannot vouch for its validity. Getting back to Kennedy's article: After Ansel met with President Reagan in July of 1983 he sent me another of his trademark typed notes, this one on the back of a card that featured an Edward Weston nude from 1936 on the front. He said: |
Ansel never got another chance to try and make Reagan come around to his passionate point of view about the environment. He died nine months later on April 22, 1984. When I got word of Ansel's passing, I was in the People's Republic of China covering President Reagan.
A different perspective, but with the same conclusion, is found on the Housatonic Museum of Art's website:
------------
12 "Playboy Interview: Ansel Adams - candid conversation,"; Playboy vol. 30, no. 5 (May 1983).
I was able to find places that would sell me an old copy, but I guess I'm not that interested. You can't see it on the little copy of the cover, but one of the articles in the May 1983 issue of Playboy was: "The Targeting of America: A Special Report on Terrorism" by Laurence Gonzales. Some things never change. And won't change, no matter how may hundreds of billions of dollars we spend.
I tried to find other references to the meeting between Ansel Adams and Reagan, but was not able to do so. There were newspaper articles at the time, but that was before newspapers started using the Internet. In fact, 1983 could be considered the year the Internet was born, because that's when ARPANET converted entirely to TCP/IP, and the Domain Name System was introduced. The WWW, though, was not established until 1992.
The newspaper reports about the meeting between Ansel Adams and Reagan were not extensive, and I recall only the overall negative tone, not the specific content. Perhaps the only transcript of the meeting, if there is one, is in the Ronald Reagan Presidential Library. The library, however, does not have much on line.
So far, my patient readers have learned that Ansel Adams was an American icon, that Gerald Ford was not a bad guy, and that Adams said, of Reagan's leadership, that "I felt with a sinking feeling that this country is in very poor hands."
Reagan did some good things. His defense spending, while extravagant almost beyond belief, contributed to the fall of the Soviet Union. Never mind that he ran up deficits so enormous that George H. W. Bush had to break his "no new taxes" pledge, which, by the way, is what opened the door to the Clinton Presidency; Bush 41 lost the support of the "Reagan Democrats" when he succumbed to the economic reality that classic tax-and-spend Republican policies simply are not sustainable.
I believe that RR was genuinely patriotic, and that he really thought that his economic and foreign policies made sense. He wanted the United States of America to be a good place. He wanted people to be nice to each other, and he set a good example with his own behavior. He did not start any wars, and he did not have any intention of using bizarre political doublespeak to justify taking taxpayer money and handing it over to huge corporations, thereby transforming rich people into filthy rich people (reference to Halliburton and KBR.)
If RR knew that "reducing the size of government" would lead to private contractors getting paid over one hundred thousand dollars a year to do what used to be done by an E-3 for eighteen thousand, he would have put a stop to it. If he had known about the Iran-Contra scandal, he would have put a stop to it. If he had understood that the Strategic Defense Initiative would be a colossal waste of money, he never would would have proposed it. If he had been in office when the Abu Ghraib scandal broke, he would have shut it down immediately, not months later.
The anniversary of the passing of Ansel Adams should be a time for reflection upon the importance of artistry in the advancement of political causes.
The passing of Ronald Reagan, likewise, should give us pause to reflect on the virtues that contribute to a great President. As reported on Netscape, in the words of Bill Clinton:
And from Jacques Chirac:
And finally, from George W. Bush (as reported in WaPo):
Both Adams and Reagan were artists: Adams a great photographer; Reagan a mediocre actor. Both had political agendas: Adams with little influence; Reagan with tremendous influence. Both were nice guys. Both were American Icons. Only Ronald Reagan got a Nimitz-class aircraft carrier named after him. Nobody is going to name a warship after Adams, but perhaps we could rename the Alaska National Wildlife Refuge the Ansel Adams National Wildlife Refuge.
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